Time passes, and Mono grows older and taller, ultimately taking on the form of the Thin Man. Alone and surrounded by the mass, Mono sits in a solitary chair and resigns himself to his fate. They outrun the mass, but Six allows Mono to fall into a chasm and escapes through a television portal. As the Signal Tower begins to crumble, the children are pursued by the gelatinous mass of flesh and eyes which forms its core. She becomes hostile when he damages her music box, but Mono returns her to normal by destroying it. Mono enters the Signal Tower and reunites with Six, now a distorted giant. Discovering he has powers similar to the Thin Man's, Mono takes his bag off and battles and disintegrates him before pulling the Signal Tower towards himself. Using various televisions as portals, Mono navigates the Pale City until Six's glitching remain leads him close to the Signal Tower, where he confronts the Thin Man. After Mono is pulled out by Six, the Thin Man emerges from the television and captures Six, leaving behind a glitching shadow of her. When Mono finally reaches the door through a television set, it opens to reveal the spectral Thin Man. They spot the Signal Tower, which emits a pervasive Transmission that controls the city's inhabitants: the television-addicted Viewers, whose faces have been distorted from exposure to it. Mono and Six then exit into the heart of the Pale City.
Mono lures the Doctor into an incinerator and may choose to kill him or leave him trapped inside. The pair reach the Hospital, where they encounter the dismembered Patients, their detached living hands, and the bulbous Doctor who crawls on the ceilings. Outside the School, Six finds her yellow raincoat. Mono rescues Six from the Bullies, and they escape the long-necked Teacher. Mono and Six enter the School, where they are separated when Six is captured by the porcelain Bullies, the School's rabid students. The player takes control of Mono, who, along with Six (the protagonist of the first game who returns as a companion non-playable character), journeys through the Pale City to reach the Signal Tower.
Like its predecessors, Little Nightmares 2 Android is a puzzle-platformer adventure game. The game also features collectible hats and glitching remains, the latter of which will unlock an additional scene upon collecting them all.
The player is also given the ability to call out to Six and hold her hand to make sure they stay together and must often work together with her to solve environmental puzzles and defeat or evade enemies. Unlike the first game, the player is not completely helpless Mono has the ability to grab certain items and swing them to break objects or to fight back against smaller foes, although he, like Six, must rely on stealth and the environment to evade larger foes. The player must explore the world, occasionally encountering platformer-like situations or being blocked by puzzles that must be solved to proceed. Little Nightmares 2 is similar to its predecessor, it takes place in a 2.5D world.